Switching from Insulin to Oral Sulfonylureas in Patients with Diabetes Lab Report

Switching from Insulin to Oral Sulfonylureas in Patients with Diabetes Due to Kir6.2 Mutations - Lab Report Example Diabetic patients have a KATP channels with decreased sensitivity to ATP inhibition because of KCNJ11 mutations. As a result of this, their channels remain open in the presence of glucose, thereby reducing insulin secretion. Ketoacidosis or marked hyperglycemia is seen in such patients with low levels of circulating endogenous insulin and are therefore treated with insulin. A class of drugs called Sulfonylureas, close KATP channels by an ATP-independent route, thereby causing insulin secretion. The authors hypothesized that sulfonylureas may represent a suitable therapy for patients with KCNJ11 mutations. The purpose of the study was to assess i) glycemic control in 49 consecutive patients with Kir6.2 mutations who received appropriate doses of sulfonylureas ii) to investigate the insulin secretory responses to intravenous and oral glucose, a mixed meal, and glucagons in smaller groups and iii) to assay the response of mutant KATP channels to the sulfonylurea tolbutamide in xenopus oocytes. A total of 49 consecutive patients from 40 families were identified as having diabetes caused by a heterozygous KCNJ11 mutation through sequencing performed in molecular genetics laboratories in Exeter, United Kingdom (34 patients), Paris (5 patients),and Bergen, Norway (10 patients) were the study participants. All 49 patients either switched from insulin to sulfonylurea therapy or were unable to switch but received an adequate dose of sulfonylureas before October 2005 were included in the study. No other selection criteria were applied. No exclusion criteria were defined by the authors and the study did not include randomization technique. As it was a cohort study, it was not possible to compare the groups. Patients with a successful switch (n =44) had the following mutations F35V, H46Y, R50Q, G53N, G53R, V59M (6 patients), K170T, R201C (5 patients), R201H (23 patients), R201L, E322K, Y330S,

Recruiting , Selecting and Orienting the Right People Research Paper

Recruiting , Selecting and Orienting the Right People - Research Paper Example The present paper has identified that before heading on to the task of defining and chalking out appropriate strategies, it is essential to take a careful and descriptive look at what factors are being presented by the current environment and what constraints might put hurdles in a selection of one strategy or the other. Also, some factors might support the choice of one or more strategies for recruitment, selection or induction. As given, the organization in question is medium-sized high technology firm. It obviates the need to incorporate cost-effectiveness in the process of recruitment, selection, and orientation because being a technology-intensive firm; it would not like its majority of funds to be invested in other organizational activities. Technology is fast changing and investment needs to be done to remain competitive in the technological market. Furthermore, prevailing situations reinforce the need of people who are zealous and ambitious to take on more responsibilities an d carry on multitasking as job duties will change with every single project assigned. An instance of stiff competition highlights the scarcity of skilled people in the labor market and as such, securing cost-effectiveness in the entire process will be a mammoth task. Theoretically, recruitment is a positive drive of creating the pool of competent candidates which are found to have fulfilled the job criteria and possess the necessary qualifications and abilities. Before proceeding for actual recruitment, it is first necessary to find out the demand. In this regard, forecasting will be done by the use of the computerized system which is obvious in a high technology firm. There are a number of recruitment techniques to choose from. However, their applicability differs on parameters of cost, effectiveness, and relevance. The figure in the paper depicts the most common recruitment techniques.